Long flights are a solved problem if you have the right gear and the right approach. Most miserable long-haul experiences come down to: wrong seat selection, bad noise management, not sleeping, or eating airport food. All of these are fixable with a little preparation and specific equipment.
The difference between flying with and without noise cancellation is the difference between a tolerable experience and an actually enjoyable one. Airplane cabin noise sits at 85dB — that's hearing-damage territory on long flights, and it's exhausting even when you don't notice it. Sony WH-1000XM5 has the best noise cancellation available and lasts 30 hours on a charge. Worth every dollar for frequent flyers.

The horseshoe-shaped blow-up pillows that everyone has are actually bad at preventing neck pain. They push your head forward. The Trtl Pillow is designed differently — it wraps around and supports the neck from the side, which is where you actually need support when sleeping in a seat. Significantly less embarrassing to use than the horseshoe. Significantly more effective.

Blood clots (deep vein thrombosis) are a real risk on long flights, especially economy class where you can't move around. Compression socks improve circulation significantly. Comrad makes the most wearable version — they look like regular socks, offer medical-grade compression (20–30mmHg is the therapeutic range), and don't feel like you're wearing a blood pressure cuff on your leg.

When you're sleeping, you don't need the headphones on. A good eye mask + cheap foam earplugs is the combination that actually lets you sleep. The Manta Sleep Mask blocks 100% of light without pressing on your eyelids. 3M 1100 earplugs reduce noise by 29dB — they're $0.30 each and they're the ones dentists and construction workers buy for actually blocking sound.

Take 0.3–1mg (low dose, not the 10mg tablets most brands sell) about 30 minutes before the time you want to sleep at your destination. This is specifically for jet lag management, not nightly use. The low dose matters — higher doses don't work better and cause grogginess. Natrol Melatonin 1mg tablets are easy to cut in half.

Aisle seat if you move a lot or hate being trapped. Window seat if you want to sleep (something to lean against, and you control the shade). Exit row or bulkhead for leg room. Never the middle. Never the last row (doesn't recline). SeatGuru.com shows you which specific seats on which planes are actually good versus which ones have the blocked window or the nonreclining seat — worth 5 minutes before you select.